Mirikitani is the Co-Founder of GLIDE, in partnership with her husband, Reverend Cecil Williams. Together they have achieved worldwide recognition for their groundbreaking organization, which empowers San Francisco’s poor and marginalized communities to make meaningful changes in their lives to break the cycle of poverty and dependence. Over five decades they built 87 comprehensive programs that provide education, recovery support, primary and mental health care, job training, housing and human services. Mirikitani's passion has been to create programs for women and families as they struggle with issues of substance use, rape, incest, domestic violence, the AIDS crisis, single parenting, childcare, health/wellness, education, and jobs development.